Mismatch repair recognises base–base mismatches and insertion/deletion loops and thus
it is essential for maintaining the fidelity of DNA replication.
1
The deficiency of DNA mismatch repair due to mutations of the proteins involved in
this mechanism predisposes to cancer and is responsible for mutator phenotype. Laboratory
studies have indicated that mismatch repair deficiency confers resistance to several
anticancer drugs, including cisplatin, methylating agents and some antimetabolites.
A significant proportion of intestinal cancers, approximately 10–15%, are mismatch
repair deficient and thus it is certainly pertinent to ask the question whether the
anticancer therapies have a different efficacy depending on mismatch repair status.To read this article in full you will need to make a payment
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References
- The multifaceted mismatch-repair system.Nat Rev Mol Cell Biol. 2006; 7: 335-346
- The efficacy of adjuvant chemotherapy with 5-fluorouracil in colorectal cancer depends on the mismatch repair status.Eur J Cancer. 2009; 45: 365-373
- MGMT gene silencing and benefit from temozolomide in glioblastoma.N Engl J Med. 2005; 352: 997-1003
- In vitro and in vivo methazolastone-induced DNA damage and repair in L-1210 leukemia sensitive and resistant to chloroethylnitrosoureas.Cancer Res. 1987; 47: 4884-4889
- Targeting DNA repair as a promising approach in cancer therapy.Eur J Cancer. 2007; 43: 1791-1801
Article info
Publication history
Published online: December 19, 2008
Accepted:
October 31,
2008
Received:
October 23,
2008
Identification
Copyright
© 2008 Elsevier Ltd. Published by Elsevier Inc. All rights reserved.
