Mismatch repair recognises base–base mismatches and insertion/deletion loops and thus it is essential for maintaining the fidelity of DNA replication.
1The deficiency of DNA mismatch repair due to mutations of the proteins involved in this mechanism predisposes to cancer and is responsible for mutator phenotype. Laboratory studies have indicated that mismatch repair deficiency confers resistance to several anticancer drugs, including cisplatin, methylating agents and some antimetabolites. A significant proportion of intestinal cancers, approximately 10–15%, are mismatch repair deficient and thus it is certainly pertinent to ask the question whether the anticancer therapies have a different efficacy depending on mismatch repair status.
- Jiricny J.
The multifaceted mismatch-repair system.
Nat Rev Mol Cell Biol. 2006; 7: 335-346
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Published online: December 19, 2008
Accepted: October 31, 2008
Received: October 23, 2008
© 2008 Elsevier Ltd. Published by Elsevier Inc. All rights reserved.