Abstract
Lymph nodes are common sites of metastatic disease in many solid tumours. Unlike most
metastases, lymph nodes are normal anatomic structures and as such, normal lymph nodes
will have a measurable size. Additionally, the imaging literature recommends that
lymph nodes be measured in the short axis, since the short axis measurement is a more
reproducible measurement and predictive of malignancy. Therefore, the RECIST committee
recommends that lymph nodes be measured in their short axis and proposes measurement
values and rules for categorising lymph nodes as normal or pathologic; either target
or non-target lesions. Data for the RECIST warehouse are presented to demonstrate
the potential change in response assessment following these rules. These standardised
lymph node guidelines are designed to be easy to implement, focus target lesion measurements
on lesions that are likely to be metastatic and prevent false progressions due to
minimal change in size.
Keywords
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Article info
Publication history
Published online: December 17, 2008
Accepted:
October 29,
2008
Received:
October 17,
2008
Identification
Copyright
© 2008 Elsevier Ltd. Published by Elsevier Inc. All rights reserved.
