Abstract
Plexins, cell-surface receptors for semaphorins, are involved in cell adhesion and
migration. In the previous work, we demonstrated that the loss of Plexin B1 expression
is associated with poor outcome in breast cancer patients. The goal of the present
study was a validation of Plexin B1 expression in a large scale microarray dataset
from n = 1086 breast cancer patients. Plexin B1 correlates with ER status (p < 0.001) and is of prognostic significance only in ER positive (p = 0.024) but not in ER negative samples (p = 0.85). Among ER positive tumours, the loss of Plexin B1 expression is associated with
a positive ErbB2 status (p = 0.05) and a high Ki67 expression (p = 0.016) in univariate analysis. Multivariate Cox regression including all standard
parameters among ER positive tumours revealed that Plexin B1 (HR 1.59, 95% confidence
interval (CI) 1.03–2.47, p = 0.036) remains a significant prognostic marker besides tumour size (HR 2.27, 95% CI
1.33–3.89, p = 0.0028) and Ki67 (HR 1.78, 95% CI 1.12–2.84, p = 0.0149). Interestingly, the prognostic value of Plexin B1 was pronounced in low proliferating
ER positive tumours otherwise characterised by a low risk of recurrence. In conclusion,
this study confirms our previous observations suggesting Plexin B1 as a new prognostic
marker in ER positive breast cancers.
Keywords
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Article info
Publication history
Published online: December 03, 2008
Accepted:
October 15,
2008
Received in revised form:
August 19,
2008
Received:
March 28,
2008
Identification
Copyright
© 2008 Elsevier Ltd. Published by Elsevier Inc. All rights reserved.
