Abstract
Background
Pro-inflammatory polymorphisms have been suggested to explain part of the individual
diversity in susceptibility to gastric carcinogenesis. We aimed to assess their impact
on the risk of chronic atrophic gastritis (CAG) in a population-based study.
Methods
Among 9953 older adults from Saarland/Germany, eight single nucleotide polymorphisms
(SNPs) were assessed for 534 cases with serologically defined CAG and 534 age- and
sex-matched controls at baseline examination.
Results
Of the 8 SNPs, only IL10 T-819C showed a borderline significant association with CAG risk (odds ratio for
CC versus TT: 1.67 (95% confidence interval: 1.01–2.76)). No significant differences
were observed for the distribution of inferred haplotypes between cases and controls.
However, joint evaluation of several cytokine variants suggested an increased risk
of CAG among individuals carrying several pro-inflammatory genotypes.
Conclusions
Our findings suggest that a pro-inflammatory genetic profile may contribute to inter-individual
variation in gastric cancer risk by increasing the susceptibility to the development
of CAG.
Keywords
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Article info
Publication history
Published online: November 17, 2008
Accepted:
September 25,
2008
Received:
September 8,
2008
Identification
Copyright
© 2008 Elsevier Ltd. Published by Elsevier Inc. All rights reserved.
