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Research Article| Volume 42, ISSUE 13, P2183-2190, September 2006

Cancer in children and adolescents in Europe: Developments over 20 years and future challenges

DOI:https://doi.org/10.1016/j.ejca.2006.06.006
Cancer in children and adolescents in Europe: Developments over 20 years and future challenges
Previous ArticleSkin cancer incidence and survival in European children and adolescents (1978–1997). Report from the Automated Childhood Cancer Information System project

      Abstract

      This special issue contains 18 articles describing population-based analyses of incidence and survival for cancer among children and adolescents in Europe over the period 1978–1997. The analyses were derived from the large database of the ACCIS project (Automated Childhood Cancer Information System), which was built through collaboration of 62 population-based cancer registries in 19 European countries. Data on 88,465 cancers in children and 15,369 in adolescents (age 15–19 yrs) were included in the various analyses, making this the largest database on cancer in these age-groups in the world. National data were grouped into five European regions to allow comparisons of incidence and survival, for all cancers and by tumour type, including analysis of trends in both over time. This overview paper focuses on the comparability of the data from multiple registries and describes the potential confounding factors. Age-standardised annual incidence rates of many, but not all, cancers in children and adolescents are clearly rising. There are geographical differences in survival for the majority of tumour types. Survival rates increased for nearly all types of cancer in children and adolescents. The implications of these findings for aetiological factors and treatment delivery for cancer in children and adolescents are discussed.

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      References

        • Steliarova-Foucher E.
        • Stiller C.
        • Kaatsch P.
        • et al.
        Geographical patterns and time trends of cancer incidence and survival among children and adolescents in Europe since 1970s: the ACCIS project.
        Lancet. 2004; 364: 2097-2105
        View in Article

      2. Parkin DM, Stiller CA, Draper GJ, Bieber CA, Terracini B, Young JL, editors. International incidence of childhood cancer. IARC Scientific Publication No. 87. Lyon: International Agency for Research on Cancer; 1988.

        View in Article

      3. Parkin DM, Kramárová E, Draper GJ, et al. (editors). International incidence of childhood cancer: Vol. 2. IARC Scientific Publication No. 144. Lyon: IARC; 1998.

        View in Article

      4. Capocaccia R, Gatta G, Magnani C, Stiller C, Coebergh J-W, editors. Childhood cancer survival in Europe 1978–1992: the EUROCARE study. Eur J Cancer 2001, 37, 671–816.

        View in Article
        • Gatta G.
        • Corazziari I.
        • Magnani C.
        • Peris-Bonet R.
        • Roazzi P.
        • Stiller C.
        The EUROCARE Working Group Childhood cancer survival in Europe.
        Ann Oncol. 2003; 14: 119-127
        View in Article
        • Kramárová E.
        • Stiller C.A.
        International classification of childhood cancer 1996.
        Int J Cancer. 1996;
        View in Article

      7. Parkin DM, Tyczynski JE, Démaret E, editors. Standards and guidelines for cancer registration in Europe. IARC Technical Publication No. 40, 2003: 69–73.

        View in Article
      8. Fritz A. Percy C. Jack A. International classification of diseases for oncology. 3rd ed. World Health Organization, Geneva2000
        View in Article

      9. Steliarova-Foucher E, Stiller C, Lacour B, Kaatsch P. International classification of childhood cancer. 3rd ed. Cancer 2005, 103, 1457–67.

        View in Article
        • Kroll M.E.
        • Draper G.J.
        • Stiller C.A.
        • Murphy M.F.G.
        Childhood leukemia incidence in Britain, 1974–2000: Time trends and possible relation to influenza epidemics.
        J Natl Cancer Inst. 2006; 98: 417-420
        View in Article
        • van der Horst M.
        • Falck Winther J.
        • Olsen J.H.
        Cancer incidence in the age range 0–34 years: Historical and actual status in Denmark.
        Int J Cancer. 2006; 118: 2816-2826
        View in Article
        • Johannesen T.B.
        • Angell-Andersen E.
        • Tretli S.
        • Langmark F.
        • Lote K.
        Trends in incidence of brain and central nervous system tumors in Norway, 1970–1999.
        Neuroepidemiology. 2004; 23: 101-109
        View in Article
        • Agha M.
        • DiMonte B.
        • Greenberg M.
        • Greenberg C.
        • Barr R.
        • McLaughlin J.R.
        Incidence trends and projections for childhood cancer in Ontario.
        Int J Cancer. 2006; 118: 2809-2815
        View in Article
        • Greaves M.
        Infection, immune responses and the aetiology of childhood leukaemia.
        Nat Rev Cancer. 2006; 6: 193-203
        View in Article
        • Terracini B.
        • Coebergh J.-W.
        • Gatta G.
        • et al.
        Childhood cancer survival in Europe: an overview.
        Eur J Cancer. 2001; 37: 810-816
        View in Article
        • Levi F.
        • La Vecchia C.
        • Negri E.
        • Lucchini F.
        Childhood cancer mortality in Europe, 1955–1995.
        Eur J Cancer. 2001; 37 (Erratum in: Eur J Cancer 2001, 37, 2289. Eur J Cancer 2001;37:1727): 785-809
        View in Article

      17. Ramanujachar R, Richards S, Hann I, Webb D. Adolescents with acute lymphoblastic leukaemia: emerging from the shadow of paediatric and adult treatment protocols. Pediatr Blood Cancer 2006 (in press). Available online: 8 February 2006.

        View in Article
        • Brenner H.
        Up-to-date survival curves of children with cancer by period analysis.
        Br J Cancer. 2003; 88: 1693-1697
        View in Article
        • Bullard J.
        • Coleman M.P.
        • Robinson D.
        • Lutz J.-M.
        • Bell J.
        • Peto J.
        Completeness of cancer registration: a new method for routine use.
        British Journal of Cancer. 2000; 82: 1111-1116
        View in Article

      20. Directive 95/46/EC of the European Parliament and of the Council of 24 October 1995. The protection of individuals with regard to processing of personal data and on the free movement of such data. Official Journal of the European Communities 1995;281:31–50.

        View in Article

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      DOI: https://doi.org/10.1016/j.ejca.2006.06.006

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      © 2006 Elsevier Ltd. Published by Elsevier Inc. All rights reserved.

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