Advertisement

Cancer incidence and survival in European adolescents (1978–1997). Report from the Automated Childhood Cancer Information System project

      Abstract

      Data on 15,399 adolescents diagnosed with cancer at age 15–19 years during 1978–1997 in Europe were extracted from the database of the Automated Childhood Cancer Information System (ACCIS). Total incidence in Europe as a whole was 186 per million in 1988–1997. Incidence among males was 1.2 times that among females. Lymphomas had the highest incidence of any diagnostic group, 46 per million, followed by epithelial tumours, 41 per million; central nervous system (CNS) tumours, 24; germ cell and gonadal tumours, 23; leukaemias, 23; bone tumours, 14; and soft tissue sarcomas, 13 per million. Total incidence varied widely between regions, from 169 per million in the East to 210 per million in the North, but lymphomas were the most frequent diagnostic group in all regions. Cancer incidence among adolescents increased significantly at a rate of 2% per year during 1978–1997. Five-year survival for all cancers combined in 1988–1997 was 73% in Europe as a whole. Survival was highest in the North, 78%, and lowest in the East, 57%. Five-year survival was generally comparable with that in the Surveillance, Epidemiology, and End Results (SEER) registries of the United States of America (USA), but for Ewing’s sarcoma it was below 45% in all European regions compared with 56% in the USA. Survival increased significantly during 1978–1997 for all cancers combined and for all diagnostic groups with sufficient registrations for analysis.

      Keywords

      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'

      Subscribe:

      Subscribe to European Journal of Cancer
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect

      References

      1. International incidence of childhood cancer. volume 2. IARC, Lyon1998
        • Capocaccia R.
        • Gatta G.
        • Magnani C.
        • et al.
        Childhood cancer survival in Europe 1978–1992: the EUROCARE study (special issue).
        Eur J Cancer. 2001; 37
        • Gatta G.
        • Corazziari I.
        • Magnani C.
        • et al.
        Childhood cancer survival in Europe.
        Ann Oncol. 2003; 14: v119-v127
        • Gatta G.
        • Capocaccia R.
        • Stiller C.
        • et al.
        Childhood cancer survival trends in Europe: A EUROCARE Working Group Study.
        J Clin Oncol. 2005; 23: 3742-3751
        • Steliarova-Foucher E.
        • Stiller C.
        • Kaatsch P.
        • et al.
        Geographical patterns and time trends of cancer incidence and survival among children and adolescents in Europe since the 1970s (the ACCIS project): an epidemiological study.
        Lancet. 2004; 364: 2097-2105
        • Gatta G.
        • Capocaccia R.
        • De Angelis R.
        • et al.
        Cancer survival in European adolescents and young adults.
        Eur J Cancer. 2003; 39: 2600-2610
      2. Eucan: Cancer Incidence, Mortality and Prevalence in the European Union. Lyon: IARC Press; 1999.

        • Kramárová E.
        • Stiller C.A.
        The international classification of childhood cancer.
        Int J Cancer. 1996; 68: 759-765
      3. Kirkwood B.R. Sterne A.C. Essential medical statistics. Blackwell Science, Oxford2003
        • Peto R.
        • Pike M.C.
        • Armitage P.
        • et al.
        Design and analysis of randomized clinical trials requiring prolonged observation of each patient. II. Analysis and examples.
        Br J Cancer. 1977; 35: 1-39
        • Birch J.M.
        • Alston R.D.
        • Quinn M.
        • Kelsey A.M.
        Incidence of malignant disease by morphological type, in young persons aged 12–24 years in England, 1979–1997.
        Eur J Cancer. 2003; 39: 2622-2631
        • Wu X.
        • Groves F.D.
        • McLaughlin C.C.
        • et al.
        Cancer incidence patterns among adolescents and young adults in the United States.
        Cancer Causes Control. 2005; 16: 309-320
        • Birch J.M.
        • Alston R.D.
        • Kelsey A.M.
        • et al.
        Classification and incidence of cancers in adolescents and young adults in England 1979–1997.
        Br J Cancer. 2002; 87: 1267-1274
        • Desandes E.
        • Lacour B.
        • Sommelet D.
        • et al.
        Cancer incidence among adolescents in France.
        Pediatr Blood Cancer. 2004; 43: 742-748
      4. Smith MA, Gurney JG, Gloeckler Ries LA. Cancer among adolescents 15–19 years old. In: Gloeckler Ries LA, Smith MA, Gurney JG, Linet M, Tamra T, Young JL, et al., editors. Cancer incidence and survival among children and adolescents: United States SEER Program 1975–1995. Bethesda, MD: NIH Pub No 99–4649. 1999, p. 157–164.

        • Gurney J.G.
        • Wall D.A.
        • Jukich P.J.
        • Davis F.G.
        The contribution of nonmalignant tumors to CNS tumor incidence rates among children in the United States.
        Cancer Causes Control. 1999; 10: 101-105
        • Richiardi L.
        • Bellocco R.
        • Adami H.-O.
        • et al.
        Testicular cancer incidence in eight northern European countries: secular and recent trends.
        Cancer Epidemiol Biomark Prev. 2004; 13: 2157-2166
        • Nachman J.
        Clinical characteristics, biological features and outcome for young adult patients with acute lymphoblastic leukaemia.
        Br J Haematol. 2005; 130: 166-173
        • Coleman M.P.
        • Gatta G.
        • Verdecchia A.
        • et al.
        EUROCARE-3 summary: cancer survival in Europe at the end of the 20th century.
        Ann Oncol. 2003; 14: v128-v149
        • Desandes E.
        • Lacour B.
        • Sommelet D.
        • et al.
        Cancer survival among adolescents in France.
        Eur J Cancer. 2006; 42: 403-409
        • Bleyer A.
        • Montello M.
        • Budd T.
        • Saxman S.
        National survival trends of young adults with sarcoma.
        Cancer. 2005; 103: 1891-1897
        • Levi F.
        • Lucchini F.
        • Negri E.
        • La Vecchia C.
        Trends in cancer mortality at age 15 to 24 years in Europe.
        Eur J Cancer. 2003; 39: 2611-2621