Abstract
Data on more than 50,000 registrations in the Automated Childhood Cancer Information
System (ACCIS) database were used to present an overview of regional patterns in childhood
cancer incidence in Europe during 1988–1997, and to present additional detail on selected
carcinomas whose occurrence in childhood is seldom described because of their rarity.
Total age-standardised incidence was 138.5 per million for Europe overall, and varied
between regions from 131.1 per million in the British Isles to 160.1 per million in
Northern Europe. Incidence varied significantly between regions for nearly all diagnostic
groups. The greatest range of regional incidence rates was for central nervous system
(CNS) tumours, from 27.0 per million in the West to 43.8 per million in the North.
Differences in registration practice for non-malignant tumours account for some of
this variation. There was a marked excess of carcinoma in Eastern Europe, which was
wholly attributable to the high incidence of thyroid carcinoma in Belarus, though
there was also evidence of inter-regional variation attributable to differences in
registration practice. The geographical heterogeneity of incidence rates for other
diagnostic groups seems more likely to reflect variations in underlying risk.
Keywords
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© 2006 Elsevier Ltd. Published by Elsevier Inc. All rights reserved.
