Abstract
Data on 5572 children and adolescents diagnosed with malignant bone tumours (International
Classification of Childhood Cancer, Group VIII) before the age of 20 years during
1978–1997 in Europe were extracted from the Automated Childhood Cancer Information
System (ACCIS) database. Age-standardised incidence among children during the period
1988–1997 was similar for boys and girls aged 0–14 years (5.5–5.6 per million). Among
adolescents aged 15–19 years, males had higher incidence (19.3 per million) than females
(10.7 per million). Among children, osteosarcoma accounted for 51% of registrations
and Ewing’s sarcoma for 41%. Among adolescents, 55% of registrations were osteosarcoma
and 28% Ewing’s sarcoma. Both tumours had their highest incidence in late childhood
or early adolescence. There were no significant time trends in incidence during 1978–1997.
Five-year survival estimates for patients diagnosed during 1988–1997 were, respectively,
59% and 51% among children and adolescents with osteosarcoma and 62% and 30% among
children and adolescents with Ewing’s sarcoma. Between 1978–1982 and 1993–1997, survival
increased for both children and adolescents with osteosarcoma, and for children with
Ewing’s sarcoma.
Keywords
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References
Parkin DM, Kramárová E, Draper GJ, et al. International incidence of childhood cancer: volume 2. In: Parkin DM, Kramárová E, Draper GJ, et al., editors. Lyon: IARC; 1998.
Smith MA, Gurney JG, Gloeckler Ries LA. Cancer among adolescents 15–19 years old. In: Gloeckler Ries LA, Smith MA, Gurney JG, et al., editors. Cancer incidence and survival among children and adolescents: United States SEER Program 1975–1995. Bethesda,MD: NIH Pub No 99-4649; 1999, p. 157–164.
World Health Organization. Pathology and genetics. tumours of soft tissue and bone. Fletcher CDM, Unni KK, Mertens F, editors. Lyon: IARC Press; 2002.
- Epidemiology of childhood cancer.IARC, Lyon1999
- Epidemiology and genetics of childhood cancer.Oncogene. 2004; 23: 6429-6444
- International variations in the incidence of childhood bone tumours.Int J Cancer. 1993; 53: 371-376
- Population-based genetic alterations in Ewing’s tumors from Japanese and European caucasian patients.Ann Oncol. 2002; 13: 1656-1664
- Hernias and Ewing’s sarcoma family of tumours: a pooled analysis and meta-analysis.Lancet Oncol. 2005; 6: 485-490
- Parental occupation and Ewing’s sarcoma: Pooled and meta-analysis.Int J Cancer. 2005; 115: 799-806
- Geographical patterns and time trends of cancer incidence and survival among children and adolescents in Europe since the 1970s (the ACCIS project): an epidemiological study.Lancet. 2004; 364: 2097-2105
- The international classification of childhood cancer.Int J Cancer. 1996; 68: 759-765
- Kirkwood B.R. Sterne A.C. Essential medical statistics. Blackwell Science Ltd, Oxford2003
Gurney JG, Swensen AR, Bulterys M. Malignant bone tumors. In: Gloeckler Ries LA, Smith MA, Gurney JG, Linet M, Tamra T, Young JL, et al., editors. Cancer incidence and survival among children and adolescents: United States SEER Program 1975–1995. Bethesda,MD: NIH Pub No 99-4649; 1999, p. 99–110.
- Incidence of malignant disease by morphological type, in young persons aged 12–24 years in England, 1979–1997.Eur J Cancer. 2003; 39: 2622-2631
- Prognostic factors in high-grade osteosarcoma of the extremities or trunk: an analysis of 1,702 patients treated on neoadjuvant cooperative osteosarcoma study group protocols.J Clin Oncol. 2002; 20: 776-790
- Prognostic factors in Ewing’s tumor of bone: analysis of 975 patients from the European Intergroup Cooperative Ewing’s Sarcoma Study Group.J Clin Oncol. 2000; 18: 3108-3114
- Patterns of care and survival for patients aged under 40 years with bone sarcoma in Britain, 1980–1994.Br J Cancer. 2006; 94: 22-29
Paulussen M, Ahrens S, Juergens HF. Cure rates in Ewing tumor patients aged over 15 years are better in pediatric oncology units. Results of GPOH CESS/EICESS studies. Proc ASCO 2003, Abstract No. 3279.
- EUROCARE Working Group. Survival of children with bone sarcoma in Europe since 1978: results from the EUROCARE study.Eur J Cancer. 2001; 37: 760-766
- Childhood cancer survival in Europe.Ann Oncol. 2003; 14: v119-v127
- Cancer survival in European adolescents and young adults.Eur J Cancer. 2003; 39: 2600-2610
- Survival of Ewing’s sarcoma patients in Hungary.Hungarian Oncol. 2000; 44: 261-264
- Chemotherapy in osteosarcoma. The Scandinavian Sarcoma Group experience.Acta Orthop Scand (Suppl). 2004; 75: 92-98
- Ewing’s sarcoma treatment in Scandinavia 1984-1990: ten-year results of the Scandinavian Sarcoma Group Protocol SSGIV.Acta Oncol. 1998; 37: 375-378
- Local therapy in localized Ewing tumors: results of 1058 patients treated in the CESS 81, CESS 86, and EICESS 92 trials.Int J Radiol Oncol Biol Phys. 2003; 55: 168-177
- Adjuvant and neoadjuvant chemotherapy for osteosarcoma of the extremities: 27 year experience at Rizzoli Institute, Italy.Eur J Cancer. 2005; 41: 2836-2845
- Prognostic factors in nonmetastatic Ewing’s sarcoma of bone treated with adjuvant chemotherapy: analysis of 359 patients at the Istituto Ortopedico Rizzoli.J Clin Oncol. 2000; 18: 4-11
Medical Research Council working party on bone sarcoma. A trial of chemotherapy in patients with osteosarcoma. (A report to the Medical Research Council by theor Working Party on Bone Sarcoma). Br J Cancer 1986;53:513–18.
- A comparison of two short intensive adjuvant chemotherapy regimens in operable osteosarcoma of limbs in children and young adults: the first study of the European Osteosarcoma Intergroup.J Clin Oncol. 1992; 10: 1579-1591
- Randomised trial of two regimens of chemotherapy in operable osteosarcoma: a study of the European Osteosarcoma Intergroup.Lancet. 1997; 350: 911-917
- Long-term results from the first UKCCSG Ewing’s Tumour Study (ET-1).Eur J Cancer. 1997; 33: 1061-1069
- Ifosfamide-containing chemotherapy in Ewing’s sarcoma: the second United Kingdom childrens’s cancer study group and the medical research council Ewing’s tumor study.J Clin Oncol. 1998; 16: 3628-3633
- Challenges in the management of bone tumors–1996.Ann N Y Acad Sci. 1997; 824: 167-179
- Treatment of Ewing sarcoma family of tumors: current status and outlook for the future.Med Pediatr Oncol. 2003; 40: 276-287
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