Abstract
This paper describes the incidence and survival of childhood central nervous system
(CNS) tumours in Europe for the period 1978–1997. A total of 19,531 cases, aged 0–14 years, from the ACCIS database were analysed by five regions: the British Isles, East,
North, South, and West. Overall age-standardised incidence rate (ASR) of CNS tumours
in Europe (1988–1997) was 29.9 per million, with the highest rates in the North. Astrocytoma (ASR = 11.8), primitive neuroectodermal tumours (PNET) (ASR = 6.5) and ependymoma (ASR = 3.4) were the most frequent types. Incidence increased significantly during 1978–1997,
on average by 1.7% per year. Diagnostic methods may partially explain incidence rates
and trends, although a role of variations in risk factors cannot be excluded. Overall
5-year survival was 64% and varied between 72% in the North and 53% in the East. PNET
had the poorest prognosis (49%) and astrocytoma the best (75%). Survival has improved
by 29% since late 1970s. The positive trends were seen in all regions, although the
interregional differences persisted, as a reflection of the different healthcare systems.
Keywords
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© 2006 Elsevier Ltd. Published by Elsevier Inc. All rights reserved.
