Abstract
To assess the risk factor of capsular rupture for individual prognosis and potential
therapeutic decision making, the present meta-analysis elaborated the prognostic significance
of perinodal spread in a large group of patients suffering from head and neck squamous
cell carcinomas (HNSCC). A review of the published literature was conducted, and fixed
and random effects models were applied for estimation of the summarised odds ratio
and 95% confidence intervals, including a test for homogeneity of the odds ratios.
Study methodology allowed the enrollment of only nine studies of 115 published papers.
Excluded studies lacked regarding primary tumour location, number and location of
lymph node metastases, values on five-year survival, or adequate follow-up data. A
summarised odds ratio of 2.7 leads to the conclusion that perinodal spread negatively
impacts the five-year survival. The lower confidence limit of more than 2 also supports
the concept that perinodal spread significantly reduces (doubled risk) the five-year-survival.
These results support the conclusion that perinodal spread is a significant adverse
risk factor for survival in patients with HNSCC.
Keywords
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Article info
Publication history
Accepted:
January 26,
2006
Received in revised form:
November 22,
2005
Received:
September 24,
2005
Identification
Copyright
© 2006 Elsevier Ltd. Published by Elsevier Inc. All rights reserved.
