Abstract
The aims of this study were reviewing our experience regarding the pulmonary toxicity
of the mammalian target of rapamycin (mTOR) inhibitor temsirolimus, discussing potential
pathogenic mechanisms and proposing management strategies. Medical records and radiological
reports of 22 patients treated with weekly doses of temsirolimus 25 mg were reviewed. Eight (36%) out of 22 patients developed pulmonary abnormalities
compatible with drug-induced pneumonitis. Half were asymptomatic and in those with
symptoms, dyspnea and dry cough were the most common. Radiologically two different
patterns, ground glass opacities and lung parenchymal consolidation, were described.
The management of this toxicity was variable, ranging from no intervention to discontinuation
of the drug. In our experience temsirolimus may cause drug-induced pneumonitis at
a higher incidence than that previously reported. The presentation and its severity
are variable. The risk of developing this toxicity may be increased among subjects
with abnormal pre-treatment pulmonary functions or history of lung disease.
Keywords
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Article info
Publication history
Accepted:
March 21,
2006
Received in revised form:
March 17,
2006
Received:
November 9,
2005
Identification
Copyright
© 2006 Elsevier Ltd. Published by Elsevier Inc. All rights reserved.
