Abstract
The aim of this study was to investigate whether the pre- and postoperative plasma
levels of tissue inhibitor of metalloproteinases-1 (TIMP-1) were associated with outcome
in colorectal cancer (CRC). Pre- and postoperative plasma TIMP-1 from 280 curatively
resected CRC patients and carcinoembryonic antigen (CEA) in corresponding serum samples
were measured and correlated with patient outcome (death, local recurrence (LR) and
distant metastases (DM)). The results showed that the course of plasma TIMP-1 from
pre- to postoperative levels correlated with patient outcome (P = 0.005). However, postoperative plasma TIMP-1 alone was strongly associated with patient
outcome, high TIMP-1 predicting short survival (P = 0.002). Combining postoperative TIMP-1 and CEA demonstrated that high TIMP-1 and CEA
levels predicted poor outcome (P < 0.0001); multivariate analysis identifying both parameters as strong prognostic factors
for survival, LR and DM (P < 0.0001). In conclusion, postoperative plasma TIMP-1 predicts patient outcome both
alone and in combination with CEA. Postoperative TIMP-1 may be a marker of residual
disease after primary surgery for CRC.
Keywords
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Article info
Publication history
Accepted:
January 13,
2006
Received in revised form:
December 24,
2005
Received:
September 15,
2005
Identification
Copyright
© 2006 Elsevier Ltd. Published by Elsevier Inc. All rights reserved.
