Abstract
Gonadotrophin-releasing hormone analogues were investigated as adjuvant treatment
for patients with node-negative, hormone-sensitive, premenopausal breast cancer. Patients
were randomised to either three cycles of cyclophosphamide, methotrexate, and 5-fluorouracil
(CMF) chemotherapy (n = 378) or goserelin every 28 d for 2 years (n = 393). During a median follow-up of 4.9 years, 123 events were observed. The first-failure
event of CMF versus goserelin, respectively, was ipsilateral locoregional recurrence
(18 versus 20), contralateral breast cancer (7 versus 6), distant failure (35 versus
24) and death without recurrence (2 versus 2). Forty-two (23 versus 19) deaths of
any cause occurred. The estimated adjusted hazard ratio for goserelin versus CMF (intention-to-treat
analysis) was 0.79 (95% CI = 0.54–1.14; P = 0.19). It is concluded that medical ovarian ablation with goserelin represents a valid
option for premenopausal patients with node-negative breast cancer.
Keywords
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Article info
Publication history
Accepted:
April 19,
2006
Received in revised form:
April 10,
2006
Received:
November 10,
2005
Identification
Copyright
© 2006 Elsevier Ltd. Published by Elsevier Inc. All rights reserved.
