Abstract
Several groups have proposed that mammary epithelial cell (MEC) populations, in common
with other epithelia, have stem and progenitor sub-populations that are long-lived
and provide most of the growth potential during ductal (and perhaps lobuloalveolar)
outgrowth. In this review, we describe what is known about normal development, particularly
with respect to the growth potential and regenerative capacity of mouse MEC populations.
We have developed a theoretical model in order to understand how the activity of the
somatic stem/progenitor cell compartment during mammary gland development could affect
the demographic of adult MEC populations. This demographic is likely to be key to
understanding tumour risk, since long-lived cells provide great advantages in the
process of cancer development.
Keywords
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Article info
Publication history
Accepted:
January 31,
2006
Received:
January 31,
2006
Identification
Copyright
© 2006 Elsevier Ltd. Published by Elsevier Inc. All rights reserved.
