Abstract
Epithelial keratinocyte regeneration has been exemplified as dependent on a population
of cellular progenitors that have retained developmental pluripotency, a latent capacity
for proliferation and differentiation with a prolonged lifespan. Recent evidence suggests
that the cell populations that regulate the development of normal tissues, and which
play vital roles in maintaining the overall homeostasis of the tissue, might be the
key target population that is essential for malignant cancer development, thus giving
rise to the notion of ‘cancer stem cells’. This review examines the leading research
into the relationship between adult stem cells in human skin marked by p63αΔN, their
putative importance in cancer development, and how we might exploit our evolving knowledge
of adult tissue stem cells to aid cancer treatments in the future. Furthermore, the
review examines information regarding ataxia telangiectasia mutated (ATM) kinase and
key regulatory events that take place on p53, only within putative keratinocyte stem
cells that are transcriptionally regulated by p63αΔN.
Keywords
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Article info
Publication history
Accepted:
January 23,
2006
Received:
January 23,
2006
Identification
Copyright
© 2006 Elsevier Ltd. Published by Elsevier Inc. All rights reserved.
