• Fran Balkwill
    Tel.: +44 20 7882 6108; fax: +44 20 7882 6110.
    Cancer Research UK, Translational Oncology Laboratory, Barts and The London, Queen Mary’s School of Medicine & Dentistry, John Vane Science Centre, Charterhouse Square, London EC1M 6BQ, United Kingdom
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      The idea that cancer and inflammation are linked is not new, but has become more prominent in the past ten years. During this time, a number of seminal papers have changed our ideas about the role of the inflammatory mediators and infiltrating host cells of the innate immune system in the cancer microenvironment. These papers are supported by definition of the cytokine and chemokine network and identification of leucocyte subsets that contribute to chronic inflammation. A study of inflammation and cancer also provides an intellectual context for understanding a fact that has been largely ignored during dissection of the genetic basis of cancer, i.e., that cancers are not only composed of genetically altered malignant cells.
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