The idea that cancer and inflammation are linked is not new, but has become more prominent
in the past ten years. During this time, a number of seminal papers have changed our
ideas about the role of the inflammatory mediators and infiltrating host cells of
the innate immune system in the cancer microenvironment. These papers are supported
by definition of the cytokine and chemokine network and identification of leucocyte
subsets that contribute to chronic inflammation. A study of inflammation and cancer
also provides an intellectual context for understanding a fact that has been largely
ignored during dissection of the genetic basis of cancer, i.e., that cancers are not
only composed of genetically altered malignant cells.
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© 2006 Elsevier Ltd. Published by Elsevier Inc. All rights reserved.
