Cancer stem cells: Opportunities for novel diagnostics and drug discovery

  • W. Nicol Keith
    Tel.: +44 141 330 4811; fax: +44 141 330 4127.
    Centre for Oncology & Applied Pharmacology, Cancer Research UK Beatson Laboratories, University of Glasgow, Garscube Estate, Switchback Road, Glasgow G61 1BD, UK
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      This special issue of the European Journal of Cancer focuses on the cancer stem cell and comprises a wide spectrum of excellent articles. Over the past five years, we have seen a steady rise in publication activity in this subject area (Fig. 1) and it seems appropriate to take stock of where we are in this rapidly emerging field. This is a topic of considerable interest to both clinical and experimental oncologists and the collection of review articles covers aspects of cancer stem cells ranging from clinical issues, such as new therapies, through to cell signalling and model systems (Fig. 2).
      Figure thumbnail gr1
      Fig. 1Publication activity in the subject area of cancer stem cells over the 5-year-period 2001–2005. As an indication of activity in the field, the phrase ‘cancer stem cells’ was used to search PubMed. The graph indicates the number of publications per year.
      Figure thumbnail gr2
      Fig. 2Converging themes in cancer stem cell research covered in this special issue of the European Journal of Cancer.
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