Abstract
Tumour-associated macrophages (TAM) represent the major inflammatory component of
the stroma of many tumours, and can affect different aspects of the neoplastic tissue.
Many observations indicate that TAM express several M2-associated pro-tumoural functions,
including promotion of angiogenesis, matrix remodelling and suppression of adaptive
immunity. The pro-tumoural role of TAM in cancer is further supported by clinical
studies that found a correlation between the high macrophage content of tumours and
poor patient prognosis. Evidence is presented here supporting the view that TAM represent
a unique and distinct M2-skewed myeloid population and are a potential target for
anti-cancer therapy.
Keywords
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Article info
Publication history
Accepted:
January 11,
2006
Received:
January 11,
2006
Identification
Copyright
© 2006 Elsevier Ltd. Published by Elsevier Inc. All rights reserved.
