Abstract
Leukocyte infiltration is a cardinal feature of almost all cancers. Chemokines are
generally responsible for eliciting local accumulation of inflammatory cells and they
appear to play the same role in the formation of peri- and intra-tumoural infiltrates.
Chronic inflammation predisposes to cancer formation and progression, and it is likely
that the chemokine system contributes to this process. In part, this may be a consequence
of its ability to attract mononuclear cells to cancer sites, where they provide growth
or angiogenic factors that enhance cancer development. However, accumulating evidence
also points to a direct effect of chemokines on cancer cells that express chemokine
receptors. In particular, some chemokines can activate anti-apoptotic pathways in
these cells. By either mechanism, tumour cells that secrete and/or respond to chemokines
would have a selective advantage. This provides another example of cancer’s ability
to co-opt host systems in order to promote tumour progression.
Keywords
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Article info
Publication history
Accepted:
January 11,
2006
Received:
January 11,
2006
Identification
Copyright
© 2006 Elsevier Ltd. Published by Elsevier Inc. All rights reserved.
