Abstract
We have evaluated risk factors associated with fatigue in 220 cancer patients during
hospitalization for stem-cell transplantation (SCT). Fatigue was assessed using a
validated one-item energy scale and a comprehensive set of fatigue predictors, at
hospital admission (baseline), day of SCT, and 7 days and 14 days after SCT. In cross-sectional
multivariate analysis, depression was the variable most consistently and strongly
associated with fatigue; other factors significantly associated with fatigue at some
time during the study included older age, higher education, smoking, lower Karnofsky
performance status, loss of appetite, nausea/vomiting, pain, higher regimen-related
toxicity, low hemoglobin level, requirement for red blood-cell transfusions, and third
year of the study period. In prospective multivariate analysis, baseline depression
showed significance or a trend towards significance in its ability to predict subsequent
measures of fatigue during hospitalization. Our findings may help to shed light on
the mechanisms underlying fatigue and may also guide future interventions.
Keywords
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Article info
Publication history
Accepted:
October 11,
2005
Received in revised form:
October 3,
2005
Received:
August 2,
2005
Identification
Copyright
© 2005 Elsevier Ltd. Published by Elsevier Inc. All rights reserved.
